Assay Detail
Binding
CHEMBL616127
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In vitro binding affinity towards cloned human 5-hydroxytryptamine 1A receptor expressed in Chinese hamster ovary (CHO) cells using [3H]8-OH-DPAT as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Serotonergic and dopaminergic activities of rigidified (R)-aporphine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.96 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122453 | — | — | 1 | 7.47 |
| CHEMBL284586 | — | — | 1 | 7.39 |
| CHEMBL120927 | — | — | 1 | 7.21 |
| CHEMBL253319 | — | — | 1 | 6.75 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 6.53 |
| CHEMBL253318 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122453 | — | Ki | = | 33.9 | nM | 7.47 |
| CHEMBL284586 | — | Ki | = | 40.7 | nM | 7.39 |
| CHEMBL120927 | — | Ki | = | 62.3 | nM | 7.21 |
| CHEMBL253319 | — | Ki | = | 178.0 | nM | 6.75 |
| CHEMBL53 | APOMORPHINE | Ki | = | 296.0 | nM | 6.53 |
| CHEMBL253318 | — | Ki | = | 373.0 | nM | 6.43 |