Assay Detail
Binding
CHEMBL616129
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In vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Dimerization of sumatriptan as an efficient way to design a potent, centrally and orally active 5-HT1B agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.02 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL158941 | — | — | 1 | 7.75 |
| CHEMBL1185 | ZOLMITRIPTAN | 4.0 | 1 | 6.91 |
| CHEMBL128 | SUMATRIPTAN | 4.0 | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL158941 | — | Ki | = | 17.7 | nM | 7.75 |
| CHEMBL1185 | ZOLMITRIPTAN | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL128 | SUMATRIPTAN | Ki | = | 407.1 | nM | 6.39 |