Assay Detail
Binding
CHEMBL616132
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Inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor serotonergic receptor in human HeLa cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HeLa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New potential uroselective NO-donor alpha1-antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.55 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL125365 | — | — | 1 | 8.92 |
| CHEMBL338608 | — | — | 1 | 8.80 |
| CHEMBL125989 | — | — | 1 | 8.66 |
| CHEMBL278865 | UPIDOSIN | 2.0 | 1 | 8.23 |
| CHEMBL338029 | — | — | 1 | 8.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL125365 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL338608 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL125989 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL278865 | UPIDOSIN | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL338029 | — | Ki | = | 7.2 | nM | 8.14 |