Assay Detail
Binding
CHEMBL616133
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Receptor binding affinity for cloned human 5-hydroxytryptamine 1A receptor in HeLa cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
5-HT1B receptor antagonist properties of novel arylpiperazide derivatives of 1-naphthylpiperazine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.62 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129661 | — | — | 1 | 8.55 |
| CHEMBL277120 | — | — | 1 | 8.04 |
| CHEMBL2112660 | — | — | 1 | 7.91 |
| CHEMBL338015 | — | — | 1 | 7.87 |
| CHEMBL129813 | — | — | 1 | 7.85 |
| CHEMBL2112662 | — | — | 1 | 7.64 |
| CHEMBL340786 | — | — | 1 | 7.30 |
| CHEMBL339308 | — | — | 1 | 7.14 |
| CHEMBL2112661 | — | — | 1 | 6.94 |
| CHEMBL128699 | — | — | 1 | 6.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129661 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL277120 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL2112660 | — | Ki | = | 12.3 | nM | 7.91 |
| CHEMBL338015 | — | Ki | = | 13.4 | nM | 7.87 |
| CHEMBL129813 | — | Ki | = | 14.1 | nM | 7.85 |
| CHEMBL2112662 | — | Ki | = | 22.7 | nM | 7.64 |
| CHEMBL340786 | — | Ki | = | 49.5 | nM | 7.30 |
| CHEMBL339308 | — | Ki | = | 71.7 | nM | 7.14 |
| CHEMBL2112661 | — | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL128699 | — | Ki | = | 117.0 | nM | 6.93 |