Assay Detail
Binding
CHEMBL616134
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Tested in vitro for its ability to bind to 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological characterization of a series of geometrically constrained 5-HT(2A/2C) receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.51 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL263881 | LYSERGIDE | 2.0 | 1 | 8.96 |
| CHEMBL116940 | — | — | 1 | 6.98 |
| CHEMBL119323 | — | — | 1 | 6.28 |
| CHEMBL331864 | — | — | 1 | 6.26 |
| CHEMBL119584 | — | — | 1 | 6.07 |
| CHEMBL445106 | — | — | 1 | 6.02 |
| CHEMBL117689 | — | — | 1 | 6.00 |
| CHEMBL116209 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL263881 | LYSERGIDE | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL116940 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL119323 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL331864 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL119584 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL445106 | — | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL117689 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL116209 | — | Ki | = | 3000.0 | nM | 5.52 |