Assay Detail
Binding
CHEMBL616135
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The binding affinity at the 5-hydroxytryptamine 1A receptor determined using [3H]5-CT
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.38 | 6.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113238 | — | — | 1 | 6.59 |
| CHEMBL324270 | — | — | 1 | 6.46 |
| CHEMBL111184 | — | — | 1 | 6.10 |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | - |
| CHEMBL654 | MIRTAZAPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113238 | — | Ki | = | 255.0 | nM | 6.59 |
| CHEMBL324270 | — | Ki | = | 345.0 | nM | 6.46 |
| CHEMBL111184 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL6437 | MIANSERIN | Ki | > | 500.0 | nM | - |
| CHEMBL654 | MIRTAZAPINE | Ki | > | 18.0 | nM | - |