Assay Detail
Binding
CHEMBL616136
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Affinity for 5-hydroxytryptamine 1A receptor subtype
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Arylpiperazide derivatives of phenylpiperazines as a new class of potent and selective 5-HT1B receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.55 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL321818 | — | — | 1 | 8.10 |
| CHEMBL15928 | GR-127935 | — | 1 | 7.14 |
| CHEMBL108722 | — | — | 1 | 7.10 |
| CHEMBL325359 | — | — | 1 | 6.59 |
| CHEMBL111302 | — | — | 1 | 6.41 |
| CHEMBL105970 | — | — | 1 | 6.41 |
| CHEMBL325131 | — | — | 1 | 6.35 |
| CHEMBL323986 | — | — | 1 | 6.24 |
| CHEMBL430500 | — | — | 1 | 6.16 |
| CHEMBL108645 | — | — | 1 | 6.00 |
| CHEMBL110601 | — | — | 1 | 5.52 |
| CHEMBL107772 | — | — | 1 | - |
| CHEMBL106807 | — | — | 1 | - |
| CHEMBL281350 | SB-224289 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL321818 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL15928 | GR-127935 | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL108722 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL325359 | — | Ki | = | 257.0 | nM | 6.59 |
| CHEMBL111302 | — | Ki | = | 393.0 | nM | 6.41 |
| CHEMBL105970 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL325131 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL323986 | — | Ki | = | 571.0 | nM | 6.24 |
| CHEMBL430500 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL108645 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL110601 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL107772 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL106807 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL281350 | SB-224289 | Ki | > | 1000.0 | nM | - |