Assay Detail
Binding
CHEMBL616156
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Binding affinity towards 5-hydroxytryptamine 1A receptor in rat hippocampus using [3H]8-OH-DPAT
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Evolution of a novel series of [(N,N-dimethylamino)propyl]- and piperazinylbenzanilides as the first selective 5-HT1D antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.54 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL311150 | — | — | 1 | 6.60 |
| CHEMBL306384 | — | — | 1 | 5.90 |
| CHEMBL72700 | — | — | 1 | 5.30 |
| CHEMBL75771 | — | — | 1 | 5.20 |
| CHEMBL309021 | — | — | 1 | 4.70 |
| CHEMBL72092 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL311150 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL306384 | — | Ki | = | 1258.93 | nM | 5.90 |
| CHEMBL72700 | — | Ki | = | 5011.87 | nM | 5.30 |
| CHEMBL75771 | — | Ki | = | 6309.57 | nM | 5.20 |
| CHEMBL309021 | — | Ki | = | 19952.62 | nM | 4.70 |
| CHEMBL72092 | — | Ki | < | 10000.0 | nM | - |