Assay Detail
Binding
CHEMBL616159
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The compound was tested for the binding affinity against 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.13 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.80 |
| CHEMBL423899 | — | — | 1 | 7.60 |
| CHEMBL136108 | — | — | 1 | 6.30 |
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 5.80 |
| CHEMBL137621 | — | — | 1 | - |
| CHEMBL136978 | — | — | 1 | - |
| CHEMBL337101 | — | — | 1 | - |
| CHEMBL342690 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL423899 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL136108 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL18772 | QUIPAZINE | Ki | = | 1584.89 | nM | 5.80 |
| CHEMBL137621 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL136978 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL337101 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL342690 | — | Ki | < | 10000.0 | nM | - |