Assay Detail
Binding
CHEMBL616165
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Concentration of compound required to inhibit cortical 5-hydroxytryptamine 1A receptor binding sites in rat brain was evaluated
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT1A receptors in the brain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.38 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26998 | — | — | 1 | 8.31 |
| CHEMBL41436 | — | — | 1 | 8.18 |
| CHEMBL164814 | — | — | 1 | 8.02 |
| CHEMBL423987 | — | — | 1 | 7.33 |
| CHEMBL168114 | — | — | 1 | 7.12 |
| CHEMBL351641 | — | — | 1 | 6.96 |
| CHEMBL349409 | — | — | 1 | 6.94 |
| CHEMBL423807 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26998 | — | IC50 | = | 4.84 | nM | 8.31 |
| CHEMBL41436 | — | IC50 | = | 6.54 | nM | 8.18 |
| CHEMBL164814 | — | IC50 | = | 9.65 | nM | 8.02 |
| CHEMBL423987 | — | IC50 | = | 46.2 | nM | 7.33 |
| CHEMBL168114 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL351641 | — | IC50 | = | 108.9 | nM | 6.96 |
| CHEMBL349409 | — | IC50 | = | 114.5 | nM | 6.94 |
| CHEMBL423807 | — | IC50 | = | 675.0 | nM | 6.17 |