Assay Detail
Binding
CHEMBL616182
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against radioligand [3H]hydroxy-2-(di-n-propylamino)-tetralin binding to 5-hydroxytryptamine 1A receptor in rat
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, structure-activity relationships, and biological characterization of novel arylalkoxyphenylalkylamine sigma ligands as potential antipsychotic drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.90 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11803 | — | — | 1 | 6.54 |
| CHEMBL545597 | — | — | 1 | 6.43 |
| CHEMBL542047 | — | — | 1 | 5.45 |
| CHEMBL521582 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11803 | — | IC50 | = | 289.0 | nM | 6.54 |
| CHEMBL545597 | — | IC50 | = | 373.0 | nM | 6.43 |
| CHEMBL542047 | — | IC50 | = | 3580.0 | nM | 5.45 |
| CHEMBL521582 | — | IC50 | = | 6460.0 | nM | 5.19 |