Assay Detail
Binding
CHEMBL616207
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity towards 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of a new model of arylpiperazines. Study of the 5-HT(1a)/alpha(1)-adrenergic receptor affinity by classical hansch analysis, artificial neural networks, and computational simulation of ligand recognition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 7.32 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL294074 | — | — | 1 | 9.22 |
| CHEMBL61545 | — | — | 1 | 8.66 |
| CHEMBL62694 | — | — | 1 | 8.47 |
| CHEMBL61614 | — | — | 1 | 8.40 |
| CHEMBL62017 | — | — | 1 | 8.32 |
| CHEMBL59791 | — | — | 1 | 8.27 |
| CHEMBL61250 | — | — | 1 | 8.26 |
| CHEMBL292315 | — | — | 1 | 8.06 |
| CHEMBL292279 | — | — | 1 | 7.92 |
| CHEMBL58006 | — | — | 1 | 7.82 |
| CHEMBL60973 | — | — | 1 | 7.82 |
| CHEMBL417381 | — | — | 1 | 7.80 |
| CHEMBL58850 | — | — | 1 | 7.57 |
| CHEMBL416266 | — | — | 1 | 7.57 |
| CHEMBL59282 | — | — | 1 | 7.55 |
| CHEMBL58702 | — | — | 1 | 7.50 |
| CHEMBL61473 | — | — | 1 | 7.47 |
| CHEMBL58197 | — | — | 1 | 7.34 |
| CHEMBL59778 | — | — | 1 | 7.32 |
| CHEMBL60078 | — | — | 1 | 7.26 |
| CHEMBL57953 | — | — | 1 | 7.19 |
| CHEMBL293365 | — | — | 1 | 7.17 |
| CHEMBL293488 | — | — | 1 | 7.04 |
| CHEMBL301637 | — | — | 1 | 6.84 |
| CHEMBL294837 | — | — | 1 | 6.75 |
| CHEMBL1202594 | — | — | 1 | 6.71 |
| CHEMBL61904 | — | — | 1 | 6.70 |
| CHEMBL417213 | — | — | 1 | 6.66 |
| CHEMBL58946 | — | — | 1 | 6.58 |
| CHEMBL59892 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL294074 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL61545 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL62694 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL61614 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL62017 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL59791 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL61250 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL292315 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL292279 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL58006 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL60973 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL417381 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL58850 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL416266 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL59282 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL58702 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL61473 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL58197 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL59778 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL60078 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL57953 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL293365 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL293488 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL301637 | — | Ki | = | 143.0 | nM | 6.84 |
| CHEMBL294837 | — | Ki | = | 179.0 | nM | 6.75 |
| CHEMBL1202594 | — | Ki | = | 193.0 | nM | 6.71 |
| CHEMBL61904 | — | Ki | = | 198.0 | nM | 6.70 |
| CHEMBL417213 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL58946 | — | Ki | = | 266.0 | nM | 6.58 |
| CHEMBL59892 | — | Ki | = | 378.0 | nM | 6.42 |
| CHEMBL59062 | — | Ki | = | 776.0 | nM | 6.11 |
| CHEMBL418638 | — | Ki | = | 808.0 | nM | 6.09 |
| CHEMBL59950 | — | Ki | = | 1182.0 | nM | 5.93 |
| CHEMBL293048 | — | Ki | = | 1232.0 | nM | 5.91 |
| CHEMBL60211 | — | Ki | = | 4614.0 | nM | 5.34 |