Assay Detail
Binding
CHEMBL616210
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity towards 5-hydroxytryptamine 1A receptor was determined using radioligand [3H]-8-OH-DPAT
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of a new model of arylpiperazines. 5. Study of the physicochemical influence of the pharmacophore on 5-HT(1a)/alpha(1)-adrenergic receptor affinity: synthesis of a new derivative with mixed 5-HT(1a)/d(2) antagonist properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 7.54 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1204234 | — | — | 1 | 8.92 |
| CHEMBL1204241 | — | — | 1 | 8.44 |
| CHEMBL1204235 | — | — | 1 | 8.43 |
| CHEMBL1204239 | — | — | 1 | 8.41 |
| CHEMBL1204250 | — | — | 1 | 8.40 |
| CHEMBL1204254 | — | — | 1 | 8.19 |
| CHEMBL1204232 | — | — | 1 | 8.07 |
| CHEMBL1204230 | — | — | 1 | 7.96 |
| CHEMBL1204253 | — | — | 1 | 7.85 |
| CHEMBL1204237 | — | — | 1 | 7.80 |
| CHEMBL1204236 | — | — | 1 | 7.62 |
| CHEMBL1204240 | — | — | 1 | 7.57 |
| CHEMBL1204258 | — | — | 1 | 7.57 |
| CHEMBL1204203 | — | — | 1 | 7.57 |
| CHEMBL1204238 | — | — | 1 | 7.51 |
| CHEMBL1204229 | — | — | 1 | 7.48 |
| CHEMBL1204244 | — | — | 1 | 7.48 |
| CHEMBL1204257 | — | — | 1 | 7.36 |
| CHEMBL1204248 | — | — | 1 | 7.22 |
| CHEMBL1204231 | — | — | 1 | 7.10 |
| CHEMBL1202594 | — | — | 1 | 6.99 |
| CHEMBL1204243 | — | — | 1 | 6.96 |
| CHEMBL1204246 | — | — | 1 | 6.90 |
| CHEMBL1204245 | — | — | 1 | 6.87 |
| CHEMBL1204252 | — | — | 1 | 6.77 |
| CHEMBL1204255 | — | — | 1 | 6.67 |
| CHEMBL1204247 | — | — | 1 | 6.49 |
| CHEMBL1204233 | — | — | 1 | 6.47 |
| CHEMBL1204228 | — | — | 1 | - |
| CHEMBL1204249 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1204234 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL1204241 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL1204235 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL1204239 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL1204250 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL1204254 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL1204232 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL1204230 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL1204253 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL1204237 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL1204236 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL1204240 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL1204258 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL1204203 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL1204238 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL1204244 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL1204229 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL1204257 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL1204248 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL1204231 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL1202594 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL1204243 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL1204246 | — | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL1204245 | — | Ki | = | 134.0 | nM | 6.87 |
| CHEMBL1204252 | — | Ki | = | 169.0 | nM | 6.77 |
| CHEMBL1204255 | — | Ki | = | 214.0 | nM | 6.67 |
| CHEMBL1204247 | — | Ki | = | 326.0 | nM | 6.49 |
| CHEMBL1204233 | — | Ki | = | 341.0 | nM | 6.47 |
| CHEMBL1204228 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1204249 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1204242 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1204251 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1204256 | — | Ki | > | 10000.0 | nM | - |