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Assay Detail

CHEMBL616217

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding activity against 5-hydroxytryptamine 3 receptor from rat cortex homogenate using [3H]-Q-ICS 205-930 as radioligand.
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 1A (CHEMBL214)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and serotonergic activity of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine and analogues: potent agonists for 5-HT1D receptors.
Street LJ, Baker R, Davey WB, Guiblin AR, Jelley RA, Reeve AJ, Routledge H, Sternfeld F, Watt AP, Beer MS.
J Med Chem (1995) 38 : 1799 -1810
PubMed 7752204 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.40 6.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL905 RIZATRIPTAN 4.0 1 6.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL905 RIZATRIPTAN IC50 = 398.11 nM 6.40