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Assay Detail

CHEMBL616221

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Ability to displace the radioligand [3H]-8-OH-DPAT from human 5-hydroxytryptamine 1A receptor
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 1A (CHEMBL214)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Tetrahydrothienopyridylbutyl-tetrahydrobenzindoles: new selective ligands of the 5-HT(7) receptor.
Kikuchi C, Hiranuma T, Koyama M.
Bioorg Med Chem Lett (2002) 12 : 2549 -2552
PubMed 12182857 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 6.20 6.29

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL314055 1 6.29
CHEMBL85602 1 6.11

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL314055 Ki = 512.86 nM 6.29
CHEMBL85602 Ki = 776.25 nM 6.11