Assay Detail
Functional
CHEMBL616223
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic affinity against cloned human 5-hydroxytryptamine 1A receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Search for alpha 1-adrenoceptor subtypes selective antagonists: design, synthesis and biological activity of cystazosin, an alpha 1D-adrenoceptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.76 | 8.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL543741 | — | — | 1 | 8.76 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | - |
| CHEMBL423294 | CYCLAZOSIN | — | 1 | - |
| CHEMBL29591 | — | — | 1 | - |
| CHEMBL27013 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL543741 | — | Ki | = | 1.738 | nM | 8.76 |
| CHEMBL2 | PRAZOSIN | Ki | < | 1000.0 | nM | - |
| CHEMBL423294 | CYCLAZOSIN | Ki | < | 1000.0 | nM | - |
| CHEMBL29591 | — | Ki | < | 1000.0 | nM | - |
| CHEMBL27013 | — | Ki | < | 1000.0 | nM | - |