Assay Detail
Binding
CHEMBL616225
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity at human 5-hydroxytryptamine 1A receptor by inhibition of [3H]8-OH-DPAT binding in Chinese hamster ovary cell line
41
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | ovary |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Improvement in the selectivity and metabolic stability of the serotonin 5-HT(1A) ligand, S 15535: a series of cis- and trans-2-(arylcycloalkylamine) 1-indanols.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 41 | 8.62 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL410530 | — | — | 1 | 9.54 |
| CHEMBL45966 | — | — | 1 | 9.52 |
| CHEMBL51457 | — | — | 1 | 9.36 |
| CHEMBL298096 | — | — | 1 | 9.35 |
| CHEMBL31354 | WAY-100,635 | — | 1 | 9.30 |
| CHEMBL48767 | — | — | 1 | 9.28 |
| CHEMBL301806 | — | — | 1 | 9.26 |
| CHEMBL300100 | — | — | 3 | 9.20 |
| CHEMBL50119 | — | — | 1 | 9.15 |
| CHEMBL298363 | — | — | 1 | 9.13 |
| CHEMBL47433 | — | — | 1 | 9.11 |
| CHEMBL49247 | — | — | 1 | 9.10 |
| CHEMBL49497 | — | — | 1 | 9.08 |
| CHEMBL300739 | — | — | 1 | 9.07 |
| CHEMBL298279 | — | — | 3 | 8.99 |
| CHEMBL298855 | — | — | 1 | 8.96 |
| CHEMBL51882 | — | — | 1 | 8.93 |
| CHEMBL299817 | — | — | 1 | 8.89 |
| CHEMBL49206 | — | — | 1 | 8.88 |
| CHEMBL297925 | — | — | 1 | 8.88 |
| CHEMBL48713 | — | — | 1 | 8.82 |
| CHEMBL299405 | — | — | 1 | 8.79 |
| CHEMBL50903 | — | — | 1 | 8.67 |
| CHEMBL48876 | — | — | 1 | 8.66 |
| CHEMBL297017 | — | — | 1 | 8.31 |
| CHEMBL412357 | — | — | 1 | 7.98 |
| CHEMBL49113 | — | — | 1 | 7.94 |
| CHEMBL49006 | — | — | 1 | 7.93 |
| CHEMBL48370 | — | — | 1 | 7.76 |
| CHEMBL51137 | — | — | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL410530 | — | Ki | = | 0.2884 | nM | 9.54 |
| CHEMBL45966 | — | Ki | = | 0.302 | nM | 9.52 |
| CHEMBL51457 | — | Ki | = | 0.4365 | nM | 9.36 |
| CHEMBL298096 | — | Ki | = | 0.4467 | nM | 9.35 |
| CHEMBL31354 | WAY-100,635 | Ki | = | 0.5012 | nM | 9.30 |
| CHEMBL48767 | — | Ki | = | 0.5248 | nM | 9.28 |
| CHEMBL301806 | — | Ki | = | 0.5495 | nM | 9.26 |
| CHEMBL300100 | — | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL50119 | — | Ki | = | 0.7079 | nM | 9.15 |
| CHEMBL298363 | — | Ki | = | 0.7413 | nM | 9.13 |
| CHEMBL47433 | — | Ki | = | 0.7762 | nM | 9.11 |
| CHEMBL49247 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL49497 | — | Ki | = | 0.8318 | nM | 9.08 |
| CHEMBL300739 | — | Ki | = | 0.8511 | nM | 9.07 |
| CHEMBL298279 | — | Ki | = | 1.023 | nM | 8.99 |
| CHEMBL298855 | — | Ki | = | 1.096 | nM | 8.96 |
| CHEMBL51882 | — | Ki | = | 1.175 | nM | 8.93 |
| CHEMBL300100 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL298279 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL299817 | — | Ki | = | 1.288 | nM | 8.89 |
| CHEMBL49206 | — | Ki | = | 1.318 | nM | 8.88 |
| CHEMBL297925 | — | Ki | = | 1.318 | nM | 8.88 |
| CHEMBL48713 | — | Ki | = | 1.514 | nM | 8.82 |
| CHEMBL299405 | — | Ki | = | 1.622 | nM | 8.79 |
| CHEMBL300100 | — | Ki | = | 2.042 | nM | 8.69 |
| CHEMBL50903 | — | Ki | = | 2.138 | nM | 8.67 |
| CHEMBL48876 | — | Ki | = | 2.188 | nM | 8.66 |
| CHEMBL297017 | — | Ki | = | 4.898 | nM | 8.31 |
| CHEMBL298279 | — | Ki | = | 6.607 | nM | 8.18 |
| CHEMBL412357 | — | Ki | = | 10.47 | nM | 7.98 |
| CHEMBL49113 | — | Ki | = | 11.48 | nM | 7.94 |
| CHEMBL49006 | — | Ki | = | 11.75 | nM | 7.93 |
| CHEMBL48370 | — | Ki | = | 17.38 | nM | 7.76 |
| CHEMBL51137 | — | Ki | = | 22.91 | nM | 7.64 |
| CHEMBL300709 | — | Ki | = | 23.44 | nM | 7.63 |
| CHEMBL49455 | — | Ki | = | 26.92 | nM | 7.57 |
| CHEMBL416283 | — | Ki | = | 67.61 | nM | 7.17 |
| CHEMBL49838 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL301518 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL300879 | — | Ki | < | 1000.0 | nM | - |
| CHEMBL49496 | — | Ki | < | 1000.0 | nM | - |