Assay Detail
Binding
CHEMBL616229
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Binding affinity towards 5-hydroxytryptamine 1A receptor (human cloned receptor) in HEK293 cells using [3H]8-OH-DPAT as radioligand;
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phen ol (SB-269970).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.18 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333784 | — | — | 1 | 6.50 |
| CHEMBL116448 | — | — | 1 | 6.40 |
| CHEMBL94984 | — | — | 1 | 6.00 |
| CHEMBL1788231 | — | — | 1 | 5.80 |
| CHEMBL282199 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333784 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL116448 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL94984 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL1788231 | — | Ki | = | 1584.89 | nM | 5.80 |
| CHEMBL282199 | — | Ki | < | 10000.0 | nM | - |