Assay Detail
Functional
CHEMBL616261
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonism of 5-hydroxytryptamine 1A receptor determined in vitro
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Studies toward the discovery of the next generation of antidepressants. Part 2: incorporating a 5-HT(1A) antagonist component into a class of serotonin reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.80 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104229 | — | — | 1 | 7.92 |
| CHEMBL421027 | — | — | 1 | 7.48 |
| CHEMBL442391 | — | — | 1 | 7.05 |
| CHEMBL104144 | — | — | 1 | 6.94 |
| CHEMBL318604 | — | — | 1 | 6.16 |
| CHEMBL322915 | — | — | 1 | 6.04 |
| CHEMBL105390 | — | — | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104229 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL421027 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL442391 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL104144 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL318604 | — | IC50 | = | 686.0 | nM | 6.16 |
| CHEMBL322915 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL105390 | — | IC50 | = | 1036.0 | nM | 5.99 |