Assay Detail
Functional
CHEMBL616262
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonism of 5-hydroxytryptamine 1A receptor was determined in vitro using a [35S]GTP-gamma-S,
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Studies toward the discovery of the next generation of antidepressants. Part 2: incorporating a 5-HT(1A) antagonist component into a class of serotonin reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.54 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104229 | — | — | 1 | 7.41 |
| CHEMBL104144 | — | — | 1 | 6.65 |
| CHEMBL318604 | — | — | 1 | 6.28 |
| CHEMBL322915 | — | — | 1 | 6.18 |
| CHEMBL105390 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104229 | — | IC50 | = | 38.9 | nM | 7.41 |
| CHEMBL104144 | — | IC50 | = | 222.0 | nM | 6.65 |
| CHEMBL318604 | — | IC50 | = | 524.0 | nM | 6.28 |
| CHEMBL322915 | — | IC50 | = | 666.0 | nM | 6.18 |
| CHEMBL105390 | — | IC50 | = | 684.0 | nM | 6.17 |