Assay Detail
Binding
CHEMBL616269
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Inhibition of human 5-hydroxytryptamine 1A receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
From hit to lead. Analyzing structure-profile relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.82 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116463 | — | — | 1 | 6.01 |
| CHEMBL326263 | — | — | 1 | 5.99 |
| CHEMBL116735 | — | — | 1 | 5.96 |
| CHEMBL325516 | — | — | 1 | 5.94 |
| CHEMBL325258 | — | — | 1 | 5.80 |
| CHEMBL326538 | — | — | 1 | 5.68 |
| CHEMBL115444 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116463 | — | IC50 | = | 985.0 | nM | 6.01 |
| CHEMBL326263 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL116735 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL325516 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL325258 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL326538 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL115444 | — | IC50 | = | 4650.0 | nM | 5.33 |