Assay Detail
Binding
CHEMBL616270
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Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor alpha expressed in HEK 293 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
5-HT1D receptor agonist properties of novel 2-[5-[[(trifluoromethyl)sulfonyl]oxy]indolyl]ethylamines and their use as synthetic intermediates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.82 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL357130 | — | — | 1 | 7.60 |
| CHEMBL142629 | — | — | 1 | 7.11 |
| CHEMBL143723 | — | — | 1 | 6.96 |
| CHEMBL143745 | — | — | 1 | 6.33 |
| CHEMBL141706 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL357130 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL142629 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL143723 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL143745 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL141706 | — | IC50 | = | 820.0 | nM | 6.09 |