Assay Detail
Binding
CHEMBL616274
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration required against [3H]8-OH-DPAT binding to cloned human 5-hydroxytryptamine 1A receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.33 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.92 |
| CHEMBL275854 | — | — | 1 | 7.71 |
| CHEMBL31115 | — | — | 1 | 7.06 |
| CHEMBL27173 | — | — | 1 | 6.54 |
| CHEMBL412876 | — | — | 1 | 6.25 |
| CHEMBL134519 | — | — | 1 | 5.42 |
| CHEMBL25800 | — | — | 1 | 5.08 |
| CHEMBL135076 | — | — | 1 | 5.06 |
| CHEMBL131736 | — | — | 1 | 4.91 |
| CHEMBL133455 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39 | SEROTONIN | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL275854 | — | IC50 | = | 19.6 | nM | 7.71 |
| CHEMBL31115 | — | IC50 | = | 86.4 | nM | 7.06 |
| CHEMBL27173 | — | IC50 | = | 287.0 | nM | 6.54 |
| CHEMBL412876 | — | IC50 | = | 562.0 | nM | 6.25 |
| CHEMBL134519 | — | IC50 | = | 3843.0 | nM | 5.42 |
| CHEMBL25800 | — | IC50 | = | 8410.0 | nM | 5.08 |
| CHEMBL135076 | — | IC50 | = | 8650.0 | nM | 5.06 |
| CHEMBL131736 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL133455 | — | IC50 | > | 10000.0 | nM | - |