Assay Detail
Binding
CHEMBL616300
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Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1A receptor expressed in CHO-K1 cells.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
5-HT1D receptor agonist properties of novel 2-[5-[[(trifluoromethyl)sulfonyl]oxy]indolyl]ethylamines and their use as synthetic intermediates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.62 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL344127 | — | — | 1 | 8.89 |
| CHEMBL143512 | — | — | 1 | 7.75 |
| CHEMBL143967 | — | — | 1 | 7.64 |
| CHEMBL143510 | — | — | 1 | 7.57 |
| CHEMBL143767 | — | — | 1 | 7.40 |
| CHEMBL128 | SUMATRIPTAN | 4.0 | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL344127 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL143512 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL143967 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL143510 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL143767 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL128 | SUMATRIPTAN | Ki | = | 341.0 | nM | 6.47 |