Assay Detail
Functional
CHEMBL616301
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Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1A receptor in CHO-K1 cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Serotonin dimers: application of the bivalent ligand approach to the design of new potent and selective 5-HT(1B/1D) agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 8.18 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL148022 | — | — | 1 | 9.00 |
| CHEMBL144030 | — | — | 1 | 8.80 |
| CHEMBL342323 | — | — | 1 | 8.78 |
| CHEMBL424128 | — | — | 1 | 8.74 |
| CHEMBL147901 | — | — | 1 | 8.66 |
| CHEMBL147677 | — | — | 1 | 8.66 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.61 |
| CHEMBL357830 | — | — | 1 | 8.40 |
| CHEMBL356277 | — | — | 1 | 8.39 |
| CHEMBL148314 | — | — | 1 | 8.37 |
| CHEMBL144397 | — | — | 1 | 8.07 |
| CHEMBL144128 | — | — | 1 | 8.02 |
| CHEMBL147851 | — | — | 1 | 8.02 |
| CHEMBL357478 | — | — | 1 | 8.01 |
| CHEMBL343196 | — | — | 1 | 7.84 |
| CHEMBL146720 | — | — | 1 | 7.70 |
| CHEMBL331240 | — | — | 1 | 6.87 |
| CHEMBL128 | SUMATRIPTAN | 4.0 | 1 | 6.36 |
| CHEMBL147206 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL148022 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL144030 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL342323 | — | Ki | = | 1.66 | nM | 8.78 |
| CHEMBL424128 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL147901 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL147677 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL39 | SEROTONIN | Ki | = | 2.48 | nM | 8.61 |
| CHEMBL357830 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL356277 | — | Ki | = | 4.06 | nM | 8.39 |
| CHEMBL148314 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL144397 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL144128 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL147851 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL357478 | — | Ki | = | 9.8 | nM | 8.01 |
| CHEMBL343196 | — | Ki | = | 14.3 | nM | 7.84 |
| CHEMBL146720 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL331240 | — | Ki | = | 134.0 | nM | 6.87 |
| CHEMBL128 | SUMATRIPTAN | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL147206 | — | Ki | > | 100.0 | nM | - |