Assay Detail
Binding
CHEMBL616305
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Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of propranolol analogues as serotonergic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 6.45 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138907 | — | — | 1 | 7.41 |
| CHEMBL140417 | — | — | 1 | 7.35 |
| CHEMBL452861 | LEVOPROPRANOLOL | 2.0 | 1 | 7.26 |
| CHEMBL337539 | — | — | 1 | 7.22 |
| CHEMBL139103 | — | — | 1 | 7.10 |
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | 7.05 |
| CHEMBL140416 | — | — | 1 | 7.02 |
| CHEMBL334465 | — | — | 1 | 6.82 |
| CHEMBL169956 | — | — | 1 | 6.65 |
| CHEMBL138136 | — | — | 1 | 6.46 |
| CHEMBL136470 | — | — | 1 | 6.40 |
| CHEMBL367935 | — | — | 1 | 6.35 |
| CHEMBL275742 | DEXPROPRANOLOL | 2.0 | 1 | 5.77 |
| CHEMBL168635 | — | — | 1 | 5.56 |
| CHEMBL168224 | — | — | 1 | 5.52 |
| CHEMBL138509 | — | — | 1 | 5.48 |
| CHEMBL170845 | — | — | 1 | 5.31 |
| CHEMBL136072 | — | — | 1 | 5.31 |
| CHEMBL139976 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138907 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL140417 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL452861 | LEVOPROPRANOLOL | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL337539 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL139103 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL27 | PROPRANOLOL | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL140416 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL334465 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL169956 | — | Ki | = | 225.0 | nM | 6.65 |
| CHEMBL138136 | — | Ki | = | 345.0 | nM | 6.46 |
| CHEMBL136470 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL367935 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL275742 | DEXPROPRANOLOL | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL168635 | — | Ki | = | 2750.0 | nM | 5.56 |
| CHEMBL168224 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL138509 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL170845 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL136072 | — | Ki | = | 4850.0 | nM | 5.31 |
| CHEMBL139976 | — | Ki | > | 25000.0 | nM | - |