Assay Detail
Binding
CHEMBL616307
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Inhibitory affinity constant against 5-hydroxytryptamine 1A receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Buspirone analogues as ligands of the 5-HT1A receptor. 1. The molecular structure of buspirone and its two analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.11 | 8.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.84 |
| CHEMBL8412 | IPSAPIRONE | 2.0 | 1 | 8.47 |
| CHEMBL297702 | — | — | 1 | 7.98 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 7.86 |
| CHEMBL299638 | — | — | 1 | 7.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56 | 8-OH-DPAT | Ki | = | 1.44 | nM | 8.84 |
| CHEMBL8412 | IPSAPIRONE | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL297702 | — | Ki | = | 10.46 | nM | 7.98 |
| CHEMBL49 | BUSPIRONE | Ki | = | 13.8 | nM | 7.86 |
| CHEMBL299638 | — | Ki | = | 38.6 | nM | 7.41 |