Assay Detail
Binding
CHEMBL616308
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Affinity against the 5-hydroxytryptamine receptor 1A using [3H]WB-4101.
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
N-aryl-N'-benzylpiperazines as potential antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 7.98 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423712 | — | — | 1 | 9.89 |
| CHEMBL1161079 | — | — | 1 | 8.92 |
| CHEMBL10105 | — | — | 1 | 8.80 |
| CHEMBL10085 | MAZAPERTINE | 2.0 | 1 | 8.77 |
| CHEMBL1161083 | — | — | 1 | 8.59 |
| CHEMBL428175 | RWJ-25730 | — | 1 | 8.48 |
| CHEMBL1161126 | — | — | 1 | 8.43 |
| CHEMBL134304 | — | — | 1 | 8.43 |
| CHEMBL340268 | — | — | 1 | 8.39 |
| CHEMBL135135 | — | — | 1 | 8.35 |
| CHEMBL1161078 | — | — | 1 | 8.29 |
| CHEMBL275045 | — | — | 1 | 8.23 |
| CHEMBL439607 | — | — | 1 | 8.21 |
| CHEMBL443546 | — | — | 1 | 8.11 |
| CHEMBL1161119 | — | — | 1 | 8.10 |
| CHEMBL1161076 | — | — | 1 | 8.07 |
| CHEMBL1161120 | — | — | 1 | 8.04 |
| CHEMBL135129 | — | — | 1 | 8.00 |
| CHEMBL416703 | — | — | 1 | 8.00 |
| CHEMBL135676 | — | — | 1 | 7.96 |
| CHEMBL135938 | — | — | 1 | 7.92 |
| CHEMBL334767 | — | — | 1 | 7.92 |
| CHEMBL1161088 | — | — | 1 | 7.92 |
| CHEMBL1161087 | — | — | 1 | 7.77 |
| CHEMBL135377 | — | — | 1 | 7.72 |
| CHEMBL1161096 | — | — | 1 | 7.70 |
| CHEMBL135047 | — | — | 1 | 7.60 |
| CHEMBL341402 | — | — | 1 | 7.60 |
| CHEMBL135479 | — | — | 1 | 7.54 |
| CHEMBL135246 | — | — | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423712 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL1161079 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL10105 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL10085 | MAZAPERTINE | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL1161083 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL428175 | RWJ-25730 | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL1161126 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL134304 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL340268 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL135135 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL1161078 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL275045 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL439607 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL443546 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL1161119 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL1161076 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL1161120 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL416703 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL135129 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL135676 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL135938 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL334767 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL1161088 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL1161087 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL135377 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL1161096 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL341402 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL135047 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL135479 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL135246 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL3392290 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL1161058 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL42 | CLOZAPINE | Ki | = | 38.5 | nM | 7.42 |
| CHEMBL135107 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL422989 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 401.0 | nM | 6.40 |
| CHEMBL134951 | — | Ki | = | 460.0 | nM | 6.34 |