Assay Detail
Binding
CHEMBL616333
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Binding affinity towards 5-hydroxytryptamine 1A receptor in rat frontal cortex using [3H]8-OH-DPAT as a radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Frontal cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Graphics computer-aided receptor mapping as a predictive tool for drug design: development of potent, selective, and stereospecific ligands for the 5-HT1A receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.75 | 9.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12129 | — | — | 1 | 9.20 |
| CHEMBL12152 | — | — | 1 | 9.10 |
| CHEMBL12311 | — | — | 1 | 8.30 |
| CHEMBL428892 | — | — | 1 | 7.02 |
| CHEMBL275742 | DEXPROPRANOLOL | 2.0 | 1 | 6.77 |
| CHEMBL11787 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12129 | — | IC50 | = | 0.631 | nM | 9.20 |
| CHEMBL12152 | — | IC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL12311 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL428892 | — | IC50 | = | 95.5 | nM | 7.02 |
| CHEMBL275742 | DEXPROPRANOLOL | IC50 | = | 169.82 | nM | 6.77 |
| CHEMBL11787 | — | IC50 | = | 794.33 | nM | 6.10 |