Assay Detail
Binding
CHEMBL616340
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against native 5-HT1A-receptors from rat hippocampus using radioligand ([3H]8-hydroxy-2-(di-n-propylamino)-tetraline) binding assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin- 1-yl]furan-2-ylmethanone (cyclazosin), a potent competitive alpha 1B- adrenoceptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.70 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 7.60 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 5.63 |
| CHEMBL423294 | CYCLAZOSIN | — | 1 | 5.21 |
| CHEMBL97698 | — | — | 1 | 5.16 |
| CHEMBL342062 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267930 | SPIPERONE | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL2 | PRAZOSIN | Ki | = | 2344.23 | nM | 5.63 |
| CHEMBL423294 | CYCLAZOSIN | Ki | = | 6165.95 | nM | 5.21 |
| CHEMBL97698 | — | Ki | = | 6918.31 | nM | 5.16 |
| CHEMBL342062 | — | Ki | = | 12882.5 | nM | 4.89 |