Assay Detail
Binding
CHEMBL616343
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]2-(di-N-propylamino)-8-hydroxytetralin binding to 5-HT1A receptor of rat frontal cortex homogenates
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Frontal cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A series of N4-imidoethyl derivatives of 1-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazine as 5-HT1A receptor ligands: synthesis and structure-affinity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.61 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL335401 | — | — | 1 | 9.15 |
| CHEMBL136494 | — | — | 1 | 8.42 |
| CHEMBL135880 | — | — | 1 | 8.33 |
| CHEMBL135885 | — | — | 1 | 8.32 |
| CHEMBL138596 | — | — | 1 | 8.19 |
| CHEMBL137482 | — | — | 1 | 8.00 |
| CHEMBL81733 | — | — | 1 | 7.49 |
| CHEMBL136748 | — | — | 1 | 7.20 |
| CHEMBL137061 | — | — | 1 | 6.96 |
| CHEMBL135888 | — | — | 1 | 6.82 |
| CHEMBL132600 | — | — | 1 | 6.46 |
| CHEMBL136493 | — | — | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL335401 | — | Ki | = | 0.7079 | nM | 9.15 |
| CHEMBL136494 | — | Ki | = | 3.802 | nM | 8.42 |
| CHEMBL135880 | — | Ki | = | 4.677 | nM | 8.33 |
| CHEMBL135885 | — | Ki | = | 4.786 | nM | 8.32 |
| CHEMBL138596 | — | Ki | = | 6.457 | nM | 8.19 |
| CHEMBL137482 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL81733 | — | Ki | = | 32.36 | nM | 7.49 |
| CHEMBL136748 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL137061 | — | Ki | = | 109.65 | nM | 6.96 |
| CHEMBL135888 | — | Ki | = | 151.36 | nM | 6.82 |
| CHEMBL132600 | — | Ki | = | 346.74 | nM | 6.46 |
| CHEMBL136493 | — | Ki | = | 977.24 | nM | 6.01 |