Assay Detail
Binding
CHEMBL616347
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Binding affinity towards 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT in rat hippocampus
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A novel series of arylpiperazines with high affinity and selectivity for the dopamine D3 receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.58 | 8.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL294747 | — | — | 1 | 8.50 |
| CHEMBL73665 | — | — | 1 | 7.90 |
| CHEMBL71960 | — | — | 1 | 7.90 |
| CHEMBL423671 | — | — | 1 | 7.70 |
| CHEMBL71894 | — | — | 1 | 6.90 |
| CHEMBL70866 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL294747 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL73665 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL71960 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL423671 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL71894 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL70866 | — | Ki | = | 251.19 | nM | 6.60 |