Assay Detail
Binding
CHEMBL616349
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Binding affinity at 5-hydroxytryptamine 1A receptor
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Characterization of potent and selective antagonists at postsynaptic 5-HT1A receptors in a series of N4-substituted arylpiperazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 8.70 | 9.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL130976 | — | — | 1 | 9.35 |
| CHEMBL337036 | — | — | 1 | 9.27 |
| CHEMBL130276 | — | — | 1 | 9.23 |
| CHEMBL130734 | — | — | 1 | 9.21 |
| CHEMBL129993 | — | — | 1 | 9.18 |
| CHEMBL8618 | NAN-190 | — | 1 | 9.15 |
| CHEMBL337078 | — | — | 1 | 9.10 |
| CHEMBL130870 | — | — | 1 | 9.10 |
| CHEMBL131184 | — | — | 1 | 8.94 |
| CHEMBL130103 | — | — | 1 | 8.90 |
| CHEMBL129947 | — | — | 1 | 8.90 |
| CHEMBL131900 | — | — | 1 | 8.89 |
| CHEMBL132878 | — | — | 1 | 8.85 |
| CHEMBL133188 | — | — | 1 | 8.80 |
| CHEMBL341391 | — | — | 1 | 8.80 |
| CHEMBL131011 | — | — | 1 | 8.76 |
| CHEMBL131018 | — | — | 1 | 8.75 |
| CHEMBL49247 | — | — | 1 | 8.75 |
| CHEMBL131198 | — | — | 1 | 8.75 |
| CHEMBL13647 | BMY-7378 | — | 1 | 8.71 |
| CHEMBL131200 | — | — | 1 | 8.70 |
| CHEMBL341390 | — | — | 1 | 8.65 |
| CHEMBL132514 | — | — | 1 | 8.56 |
| CHEMBL335752 | — | — | 1 | 8.55 |
| CHEMBL335010 | — | — | 1 | 8.55 |
| CHEMBL335297 | — | — | 1 | 8.50 |
| CHEMBL128546 | — | — | 1 | 8.50 |
| CHEMBL132657 | — | — | 1 | 8.43 |
| CHEMBL127216 | — | — | 1 | 8.42 |
| CHEMBL334381 | — | — | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL130976 | — | Ki | = | 0.4467 | nM | 9.35 |
| CHEMBL337036 | — | Ki | = | 0.537 | nM | 9.27 |
| CHEMBL130276 | — | Ki | = | 0.5888 | nM | 9.23 |
| CHEMBL130734 | — | Ki | = | 0.6166 | nM | 9.21 |
| CHEMBL129993 | — | Ki | = | 0.6607 | nM | 9.18 |
| CHEMBL8618 | NAN-190 | Ki | = | 0.7079 | nM | 9.15 |
| CHEMBL337078 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL130870 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL131184 | — | Ki | = | 1.148 | nM | 8.94 |
| CHEMBL130103 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL129947 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL131900 | — | Ki | = | 1.288 | nM | 8.89 |
| CHEMBL132878 | — | Ki | = | 1.413 | nM | 8.85 |
| CHEMBL133188 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL341391 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL131011 | — | Ki | = | 1.738 | nM | 8.76 |
| CHEMBL131198 | — | Ki | = | 1.778 | nM | 8.75 |
| CHEMBL49247 | — | Ki | = | 1.778 | nM | 8.75 |
| CHEMBL131018 | — | Ki | = | 1.778 | nM | 8.75 |
| CHEMBL13647 | BMY-7378 | Ki | = | 1.95 | nM | 8.71 |
| CHEMBL131200 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL341390 | — | Ki | = | 2.239 | nM | 8.65 |
| CHEMBL132514 | — | Ki | = | 2.754 | nM | 8.56 |
| CHEMBL335752 | — | Ki | = | 2.818 | nM | 8.55 |
| CHEMBL335010 | — | Ki | = | 2.818 | nM | 8.55 |
| CHEMBL128546 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL335297 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL132657 | — | Ki | = | 3.715 | nM | 8.43 |
| CHEMBL127216 | — | Ki | = | 3.802 | nM | 8.42 |
| CHEMBL334381 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL337279 | — | Ki | = | 6.607 | nM | 8.18 |
| CHEMBL131324 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL133838 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL282614 | ELTOPRAZINE | Ki | = | 9.333 | nM | 8.03 |
| CHEMBL38288 | — | Ki | = | 32.36 | nM | 7.49 |