Assay Detail
Binding
CHEMBL616366
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Binding affinity for 5-hydroxytryptamine 1A receptor determined using [3H]8-OH-DPAT as radioligand
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New 1-aryl-4-(biarylmethylene)piperazines as potential atypical antipsychotics sharing dopamine D(2)-receptor and serotonin 5-HT(1A)-receptor affinities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 7.59 | 9.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77472 | — | — | 1 | 9.04 |
| CHEMBL58377 | — | — | 1 | 9.00 |
| CHEMBL292187 | ELOPIPRAZOLE | 2.0 | 1 | 8.82 |
| CHEMBL80230 | — | — | 1 | 8.12 |
| CHEMBL76990 | — | — | 1 | 8.11 |
| CHEMBL78058 | — | — | 1 | 8.10 |
| CHEMBL218166 | BIFEPRUNOX | 3.0 | 1 | 8.03 |
| CHEMBL306830 | — | — | 1 | 7.85 |
| CHEMBL78241 | — | — | 1 | 7.82 |
| CHEMBL308345 | — | — | 1 | 7.80 |
| CHEMBL310045 | — | — | 1 | 7.77 |
| CHEMBL74805 | — | — | 1 | 7.68 |
| CHEMBL309215 | — | — | 1 | 7.68 |
| CHEMBL80156 | — | — | 1 | 7.64 |
| CHEMBL310048 | — | — | 1 | 7.58 |
| CHEMBL75621 | — | — | 1 | 7.50 |
| CHEMBL420016 | — | — | 1 | 7.50 |
| CHEMBL305834 | — | — | 1 | 7.46 |
| CHEMBL308875 | — | — | 1 | 7.42 |
| CHEMBL77334 | — | — | 1 | 7.39 |
| CHEMBL77934 | — | — | 1 | 7.38 |
| CHEMBL305920 | — | — | 1 | 7.31 |
| CHEMBL308476 | — | — | 1 | 7.07 |
| CHEMBL306634 | — | — | 1 | 6.89 |
| CHEMBL419275 | — | — | 1 | 6.70 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 6.60 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.57 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77472 | — | Ki | = | 0.91 | nM | 9.04 |
| CHEMBL58377 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL292187 | ELOPIPRAZOLE | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL80230 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL76990 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL78058 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL218166 | BIFEPRUNOX | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL306830 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL78241 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL308345 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL310045 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL74805 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL309215 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL80156 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL310048 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL75621 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL420016 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL305834 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL308875 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL77334 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL77934 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL305920 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL308476 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL306634 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL419275 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL85 | RISPERIDONE | Ki | = | 253.0 | nM | 6.60 |
| CHEMBL42 | CLOZAPINE | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 2800.0 | nM | 5.55 |