Assay Detail
Binding
CHEMBL616369
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Binding affinity to 5-hydroxytryptamine 1A receptor was determined
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Conformational analysis of tandospirone in aqueous solution: lead evolution of potent dopamine D4 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.42 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274047 | TANDOSPIRONE | 2.0 | 1 | 7.50 |
| CHEMBL15270 | — | — | 1 | 6.80 |
| CHEMBL407641 | MEZILAMINE | 2.0 | 1 | 6.37 |
| CHEMBL14899 | — | — | 1 | 6.34 |
| CHEMBL14998 | — | — | 1 | 5.82 |
| CHEMBL15242 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274047 | TANDOSPIRONE | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL15270 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL407641 | MEZILAMINE | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL14899 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL14998 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL15242 | — | Ki | = | 2000.0 | nM | 5.70 |