Assay Detail
Binding
CHEMBL616373
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Displacement of [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor expressed in CHO cell membranes
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel indolodioxanes with antihypertensive effects: potent ligands for the 5-HT1A receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.93 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318374 | — | — | 1 | 9.70 |
| CHEMBL320880 | — | — | 1 | 9.52 |
| CHEMBL317433 | — | — | 1 | 9.40 |
| CHEMBL101535 | — | — | 1 | 9.30 |
| CHEMBL418802 | — | — | 1 | 9.22 |
| CHEMBL323088 | — | — | 1 | 9.22 |
| CHEMBL320173 | — | — | 1 | 9.05 |
| CHEMBL318166 | — | — | 1 | 9.00 |
| CHEMBL319023 | — | — | 1 | 8.92 |
| CHEMBL103983 | — | — | 1 | 8.80 |
| CHEMBL102175 | — | — | 1 | 8.52 |
| CHEMBL106283 | — | — | 1 | 7.75 |
| CHEMBL101483 | — | — | 1 | 7.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318374 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL320880 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL317433 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL101535 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL418802 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL323088 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL320173 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL318166 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL319023 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL103983 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL102175 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL106283 | — | Ki | = | 17.8 | nM | 7.75 |
| CHEMBL101483 | — | Ki | = | 22.0 | nM | 7.66 |