Assay Detail
Binding
CHEMBL616393
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Ability to displace [3H]8-OH-DPAT radioligand from porcine 5-hydroxytryptamine 1A receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2,4-Disubstituted pyrroles: synthesis, traceless linking and pharmacological investigations leading to the dopamine D4 receptor partial agonist FAUC 356.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.33 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57176 | — | — | 1 | 6.57 |
| CHEMBL56118 | — | — | 1 | 6.35 |
| CHEMBL2113718 | — | — | 1 | 6.29 |
| CHEMBL60815 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57176 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL56118 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL2113718 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL60815 | — | Ki | = | 790.0 | nM | 6.10 |