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Assay Detail

CHEMBL616403

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]8-OH-DPAT from pig cortex 5-hydroxytryptamine 1A receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Sus scrofa
Confidence 8 — Homologous single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 1A (CHEMBL214)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and serotonergic activity of 5-(oxadiazolyl)tryptamines: potent agonists for 5-HT1D receptors.
Street LJ, Baker R, Castro JL, Chambers MS, Guiblin AR, Hobbs SC, Matassa VG, Reeve AJ, Beer MS, Middlemiss DN.
J Med Chem (1993) 36 : 1529 -1538
PubMed 8496922 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 7.37 8.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL39317 L-694247 1 8.50
CHEMBL39331 1 8.30
CHEMBL289489 1 8.30
CHEMBL288821 1 7.90
CHEMBL39636 1 7.80
CHEMBL38482 1 7.50
CHEMBL37462 1 7.30
CHEMBL290587 1 7.30
CHEMBL36497 1 7.20
CHEMBL37317 1 6.50
CHEMBL39243 1 6.50
CHEMBL39712 1 6.40
CHEMBL39296 1 6.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL39317 L-694247 IC50 = 3.162 nM 8.50
CHEMBL39331 IC50 = 5.012 nM 8.30
CHEMBL289489 IC50 = 5.012 nM 8.30
CHEMBL288821 IC50 = 12.59 nM 7.90
CHEMBL39636 IC50 = 15.85 nM 7.80
CHEMBL38482 IC50 = 31.62 nM 7.50
CHEMBL37462 IC50 = 50.12 nM 7.30
CHEMBL290587 IC50 = 50.12 nM 7.30
CHEMBL36497 IC50 = 63.1 nM 7.20
CHEMBL37317 IC50 = 316.23 nM 6.50
CHEMBL39243 IC50 = 316.23 nM 6.50
CHEMBL39712 IC50 = 398.11 nM 6.40
CHEMBL39296 IC50 = 501.19 nM 6.30