Assay Detail
Binding
CHEMBL616420
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity of compound against 5-hydroxytryptamine 1A receptor binding site using radioligand [3H]8-OH-DPAT
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
5-HT1A-receptor antagonism: N-alkyl derivatives of (R)-(-)-8,11-dimethoxynoraporphine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.72 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.68 |
| CHEMBL300329 | — | — | 1 | 8.07 |
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 7.52 |
| CHEMBL61377 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56 | 8-OH-DPAT | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL300329 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL267930 | SPIPERONE | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL61377 | — | Ki | = | 240.0 | nM | 6.62 |