Assay Detail
Binding
CHEMBL616428
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Binding affinity against 5-hydroxytryptamine 1A receptor of rat hippocampus tissue.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.24 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41436 | — | — | 1 | 8.92 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.14 |
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 5.44 |
| CHEMBL43304 | — | — | 1 | 5.39 |
| CHEMBL288069 | — | — | 1 | 4.92 |
| CHEMBL43512 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41436 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL39 | SEROTONIN | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL18772 | QUIPAZINE | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL43304 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL288069 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL43512 | — | Ki | = | 24000.0 | nM | 4.62 |