Assay Detail
Binding
CHEMBL616518
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Compound was evaluated for binding affinity towards 5-hydroxytryptamine 1D receptor in bovine caudate using [3H]- serotonin as radioligand
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
1-(2-Aminoethyl)-3-methyl-8,9-dihydropyrano[3,2-e]indole: a rotationally restricted phenolic analog of the neurotransmitter serotonin and agonist selective for serotonin (5-HT2-type) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.99 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27173 | — | — | 1 | 6.96 |
| CHEMBL412876 | — | — | 1 | 6.66 |
| CHEMBL122860 | — | — | 1 | 5.92 |
| CHEMBL25800 | — | — | 1 | 5.38 |
| CHEMBL26427 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27173 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL412876 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL122860 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL25800 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL26427 | — | IC50 | = | 9300.0 | nM | 5.03 |