Assay Detail
Binding
CHEMBL616548
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The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 1D receptor in CHO cells, using [3H]5-HT as radioligand
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Bicyclic piperazinylbenzenesulphonamides are potent and selective 5-HT6 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.74 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29433 | — | — | 1 | 7.00 |
| CHEMBL282971 | — | — | 1 | 6.90 |
| CHEMBL29846 | — | — | 1 | 6.70 |
| CHEMBL431298 | — | — | 1 | 6.60 |
| CHEMBL29410 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29433 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL282971 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL29846 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL431298 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL29410 | — | Ki | = | 316.23 | nM | 6.50 |