Assay Detail
Binding
CHEMBL616556
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Binding affinity to 5-HT1B receptors using rat cortex+striatum + globus pallidus,[3H]-5-OH-tryptamine, and serotonin for NSB
20
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
5-hydroxytryptamine receptor 1B (CHEMBL3459) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
3-amino-3,4-dihydro-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 2. Synthesis and quantitative structure-activity relationship studies of spiro[pyrrolidine- and piperidine-2,3'(2'H)-benzopyrans]
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.05 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11265 | — | — | 3 | 5.89 |
| CHEMBL422283 | — | — | 1 | 5.66 |
| CHEMBL133375 | — | — | 1 | 5.57 |
| CHEMBL135952 | — | — | 1 | 5.42 |
| CHEMBL137643 | — | — | 1 | 5.36 |
| CHEMBL11592 | — | — | 3 | 5.30 |
| CHEMBL422453 | — | — | 1 | 4.96 |
| CHEMBL283606 | — | — | 1 | 4.70 |
| CHEMBL8412 | IPSAPIRONE | 2.0 | 1 | 4.30 |
| CHEMBL137486 | — | — | 1 | 4.29 |
| CHEMBL137478 | — | — | 1 | 4.16 |
| CHEMBL135490 | — | — | 1 | - |
| CHEMBL132970 | — | — | 1 | - |
| CHEMBL135489 | — | — | 1 | - |
| CHEMBL135335 | — | — | 1 | - |
| CHEMBL137642 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11265 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL422283 | — | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL133375 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL135952 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL11265 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL137643 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL11592 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL11592 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL11592 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL422453 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL283606 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL11265 | — | IC50 | = | 31100.0 | nM | 4.51 |
| CHEMBL8412 | IPSAPIRONE | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL137486 | — | IC50 | = | 51100.0 | nM | 4.29 |
| CHEMBL137478 | — | IC50 | = | 69100.0 | nM | 4.16 |
| CHEMBL137642 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL135335 | — | IC50 | = | 246000.0 | nM | - |
| CHEMBL135489 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL132970 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL135490 | — | IC50 | > | 1000000.0 | nM | - |