Assay Detail
Binding
CHEMBL616569
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to displace [3H]2-(di-N-propylamino)-8-hydroxy-tetralin from 5-hydroxytryptamine 1A (5-HT1A) receptor in rat frontal cortex homogenates
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Frontal cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Structure-affinity relationship studies on 5-HT1A receptor ligands. 2. Heterobicyclic phenylpiperazines with N4-aralkyl substituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 43 | 8.49 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL555633 | — | — | 1 | 9.82 |
| CHEMBL92242 | — | — | 1 | 9.70 |
| CHEMBL543851 | — | — | 1 | 9.60 |
| CHEMBL81728 | — | — | 1 | 9.52 |
| CHEMBL543139 | — | — | 1 | 9.49 |
| CHEMBL545720 | — | — | 1 | 9.43 |
| CHEMBL93421 | — | — | 1 | 9.36 |
| CHEMBL543141 | — | — | 1 | 9.34 |
| CHEMBL538273 | — | — | 1 | 9.33 |
| CHEMBL27457 | — | — | 1 | 9.30 |
| CHEMBL27558 | — | — | 1 | 9.27 |
| CHEMBL285158 | — | — | 1 | 9.21 |
| CHEMBL542671 | — | — | 1 | 9.17 |
| CHEMBL542906 | — | — | 1 | 9.14 |
| CHEMBL26834 | — | — | 1 | 9.09 |
| CHEMBL545722 | — | — | 1 | 9.07 |
| CHEMBL545721 | — | — | 1 | 9.02 |
| CHEMBL541077 | — | — | 1 | 9.00 |
| CHEMBL94115 | — | — | 1 | 9.00 |
| CHEMBL543377 | — | — | 1 | 8.85 |
| CHEMBL26988 | — | — | 1 | 8.77 |
| CHEMBL26601 | — | — | 1 | 8.66 |
| CHEMBL543138 | — | — | 1 | 8.40 |
| CHEMBL96595 | — | — | 1 | 8.24 |
| CHEMBL280825 | — | — | 1 | 8.23 |
| CHEMBL27655 | — | — | 1 | 8.11 |
| CHEMBL26355 | — | — | 1 | 8.10 |
| CHEMBL286287 | — | — | 1 | 8.09 |
| CHEMBL554093 | — | — | 1 | 7.96 |
| CHEMBL28288 | — | — | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL555633 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL92242 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL543851 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL81728 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL543139 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL545720 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL93421 | — | Ki | = | 0.44 | nM | 9.36 |
| CHEMBL543141 | — | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL538273 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL27457 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL27558 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL285158 | — | Ki | = | 0.61 | nM | 9.21 |
| CHEMBL542671 | — | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL542906 | — | Ki | = | 0.73 | nM | 9.14 |
| CHEMBL26834 | — | Ki | = | 0.81 | nM | 9.09 |
| CHEMBL545722 | — | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL545721 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL541077 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL94115 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL543377 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL26988 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL26601 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL543138 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL96595 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL280825 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL27655 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL26355 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL286287 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL554093 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL28288 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL61032 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL416382 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL542184 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL329246 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL27694 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL92745 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL26645 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL282614 | ELTOPRAZINE | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL26819 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL28110 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL96658 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL26905 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL27590 | — | Ki | = | 80.0 | nM | 7.10 |