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Assay Detail

CHEMBL616571

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Binding
Tested for the binding affinity against the site labelled by the 5-hydroxytryptamine 1A receptor agonist [3H]- 8-OH-DPAT
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 1A (CHEMBL273)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

1-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl)-2-aminopropane: a potent serotonin 5-HT2A/2C agonist.
Nichols DE, Frescas S, Marona-Lewicka D, Huang X, Roth BL, Gudelsky GA, Nash JF.
J Med Chem (1994) 37 : 4346 -4351
PubMed 7996545 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 5.56 5.65

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL6620 1 5.65
CHEMBL136354 1 5.47

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL6620 Ki = 2225.0 nM 5.65
CHEMBL136354 Ki = 3422.0 nM 5.47