Assay Detail
Binding
CHEMBL616572
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Tested for the inhibitory activity against 5-hydroxytryptamine 1A receptor in rat hippocampal
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Iodinated 2-aminotetralins and 3-amino-1-benzopyrans: ligands for dopamine D2 and D3 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.90 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL110239 | — | — | 1 | 8.29 |
| CHEMBL263282 | — | — | 1 | 7.32 |
| CHEMBL285755 | — | — | 1 | 7.14 |
| CHEMBL336851 | — | — | 1 | 6.53 |
| CHEMBL133085 | — | — | 1 | 6.21 |
| CHEMBL138015 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL110239 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL263282 | — | Ki | = | 47.9 | nM | 7.32 |
| CHEMBL285755 | — | Ki | = | 72.7 | nM | 7.14 |
| CHEMBL336851 | — | Ki | = | 297.0 | nM | 6.53 |
| CHEMBL133085 | — | Ki | = | 619.0 | nM | 6.21 |
| CHEMBL138015 | — | Ki | = | 1273.0 | nM | 5.89 |