Assay Detail
Binding
CHEMBL616573
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested in vitro for binding affinity by measuring its ability to inhibit [3H]8-OH-DPAT binding at 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes.
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of a new model of arylpiperazines. 2. Three-dimensional quantitative structure-activity relationships of hydantoin-phenylpiperazine derivatives with affinity for 5-HT1A and alpha 1 receptors. A comparison of CoMFA models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 38 | 6.86 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46918 | — | — | 1 | 8.62 |
| CHEMBL42706 | — | — | 1 | 8.42 |
| CHEMBL43992 | — | — | 1 | 8.39 |
| CHEMBL289873 | — | — | 1 | 8.36 |
| CHEMBL42810 | — | — | 1 | 8.26 |
| CHEMBL45253 | — | — | 1 | 8.24 |
| CHEMBL42644 | — | — | 1 | 8.14 |
| CHEMBL46881 | — | — | 1 | 8.06 |
| CHEMBL417709 | — | — | 1 | 8.00 |
| CHEMBL290039 | — | — | 1 | 7.95 |
| CHEMBL290203 | — | — | 1 | 7.72 |
| CHEMBL43332 | — | — | 1 | 7.61 |
| CHEMBL296713 | — | — | 1 | 7.34 |
| CHEMBL44786 | — | — | 1 | 7.27 |
| CHEMBL416984 | — | — | 1 | 7.25 |
| CHEMBL296413 | — | — | 1 | 7.24 |
| CHEMBL42396 | — | — | 1 | 7.18 |
| CHEMBL42404 | — | — | 1 | 7.11 |
| CHEMBL46885 | — | — | 1 | 7.05 |
| CHEMBL1202594 | — | — | 1 | 6.99 |
| CHEMBL47200 | — | — | 1 | 6.91 |
| CHEMBL46525 | — | — | 1 | 6.89 |
| CHEMBL41978 | — | — | 1 | 6.81 |
| CHEMBL46535 | — | — | 1 | 6.63 |
| CHEMBL46802 | — | — | 1 | 6.38 |
| CHEMBL45007 | — | — | 1 | 6.22 |
| CHEMBL46677 | — | — | 1 | 5.93 |
| CHEMBL291165 | — | — | 1 | 5.87 |
| CHEMBL44876 | — | — | 1 | 5.59 |
| CHEMBL296724 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46918 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL42706 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL43992 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL289873 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL42810 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL45253 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL42644 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL46881 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL417709 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL290039 | — | Ki | = | 11.3 | nM | 7.95 |
| CHEMBL290203 | — | Ki | = | 19.2 | nM | 7.72 |
| CHEMBL43332 | — | Ki | = | 24.8 | nM | 7.61 |
| CHEMBL296713 | — | Ki | = | 45.5 | nM | 7.34 |
| CHEMBL44786 | — | Ki | = | 53.6 | nM | 7.27 |
| CHEMBL416984 | — | Ki | = | 55.9 | nM | 7.25 |
| CHEMBL296413 | — | Ki | = | 57.9 | nM | 7.24 |
| CHEMBL42396 | — | Ki | = | 65.8 | nM | 7.18 |
| CHEMBL42404 | — | Ki | = | 78.5 | nM | 7.11 |
| CHEMBL46885 | — | Ki | = | 89.9 | nM | 7.05 |
| CHEMBL1202594 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL47200 | — | Ki | = | 123.0 | nM | 6.91 |
| CHEMBL46525 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL41978 | — | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL46535 | — | Ki | = | 234.0 | nM | 6.63 |
| CHEMBL46802 | — | Ki | = | 418.0 | nM | 6.38 |
| CHEMBL45007 | — | Ki | = | 598.0 | nM | 6.22 |
| CHEMBL46677 | — | Ki | = | 1183.0 | nM | 5.93 |
| CHEMBL291165 | — | Ki | = | 1349.0 | nM | 5.87 |
| CHEMBL44876 | — | Ki | = | 2582.0 | nM | 5.59 |
| CHEMBL296724 | — | Ki | = | 7550.0 | nM | 5.12 |
| CHEMBL289784 | — | Ki | = | 19274.0 | nM | 4.71 |
| CHEMBL432495 | — | Ki | = | 23932.0 | nM | 4.62 |
| CHEMBL47040 | — | Ki | = | 23932.0 | nM | 4.62 |
| CHEMBL298286 | — | Ki | = | 30618.0 | nM | 4.51 |
| CHEMBL42219 | — | Ki | = | 93590.0 | nM | 4.03 |
| CHEMBL46377 | — | Ki | = | 168260.0 | nM | - |
| CHEMBL297882 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL46651 | — | Ki | = | 501187.0 | nM | - |