Assay Detail
Binding
CHEMBL616574
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Tested in vitro for receptor binding affinity against 5-hydroxytryptamine 1A receptor using radioligand [3H]8-OH-DPAT
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.43 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93781 | — | — | 1 | 8.40 |
| CHEMBL91806 | — | — | 1 | 7.82 |
| CHEMBL93454 | — | — | 1 | 7.77 |
| CHEMBL327198 | — | — | 1 | 7.62 |
| CHEMBL92886 | — | — | 1 | 7.39 |
| CHEMBL418953 | — | — | 1 | 7.38 |
| CHEMBL26789 | — | — | 1 | 7.24 |
| CHEMBL91689 | — | — | 1 | 6.69 |
| CHEMBL92887 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93781 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL91806 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL93454 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL327198 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL92886 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL418953 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL26789 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL91689 | — | Ki | = | 203.0 | nM | 6.69 |
| CHEMBL92887 | — | Ki | = | 249.0 | nM | 6.60 |