Assay Detail
Binding
CHEMBL616582
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The compound was tested for binding affinity on [3H]8-OH-DPAT as specific ligand on 5-hydroxytryptamine 1A receptor in rat hippocampus
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel adrenoceptor antagonists with a tricyclic pyrrolodipyridazine skeleton.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.31 | 8.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.63 |
| CHEMBL301078 | — | — | 1 | 7.79 |
| CHEMBL51074 | — | — | 1 | 7.67 |
| CHEMBL49851 | — | — | 1 | 7.25 |
| CHEMBL301726 | — | — | 1 | 6.91 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56 | 8-OH-DPAT | Ki | = | 2.33 | nM | 8.63 |
| CHEMBL301078 | — | Ki | = | 16.3 | nM | 7.79 |
| CHEMBL51074 | — | Ki | = | 21.2 | nM | 7.67 |
| CHEMBL49851 | — | Ki | = | 56.5 | nM | 7.25 |
| CHEMBL301726 | — | Ki | = | 123.0 | nM | 6.91 |
| CHEMBL2 | PRAZOSIN | Ki | = | 2360.0 | nM | 5.63 |