Assay Detail
Binding
CHEMBL616586
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Binding affinity towards 5-hydroxytryptamine 1A receptor by displacing [3H]WB-4101 from rat hippocampus
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pyrrole mannich bases as potential antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.97 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL346168 | — | — | 1 | 8.77 |
| CHEMBL153136 | — | — | 1 | 8.74 |
| CHEMBL428175 | RWJ-25730 | — | 1 | 8.48 |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | 8.30 |
| CHEMBL434512 | — | — | 1 | 8.27 |
| CHEMBL9666 | — | — | 1 | 8.02 |
| CHEMBL153490 | — | — | 1 | 7.76 |
| CHEMBL347334 | — | — | 1 | 7.52 |
| CHEMBL153451 | — | — | 1 | 7.46 |
| CHEMBL422 | TRIFLUOPERAZINE | 4.0 | 1 | 6.39 |
| CHEMBL267044 | LEVOSULPIRIDE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL346168 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL153136 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL428175 | RWJ-25730 | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL49 | BUSPIRONE | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL434512 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL9666 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL153490 | — | Ki | = | 17.2 | nM | 7.76 |
| CHEMBL347334 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL153451 | — | Ki | = | 34.3 | nM | 7.46 |
| CHEMBL422 | TRIFLUOPERAZINE | Ki | = | 411.0 | nM | 6.39 |
| CHEMBL267044 | LEVOSULPIRIDE | Ki | > | 1000.0 | nM | - |